Gastroparesis (GP) is a chronic disorder of the stomach which presents with early satiety, nausea, vomiting, bloating, and upper abdominal discomfort and is characterized by delayed gastric emptying.
Normal gastric emptying reflects a coordinated effort between different regions of the stomach and the duodenum as well as extrinsic modulation by central nervous system (CNS) and distal gut factors.
GP disrupts this coordinated contractile effort. Female account for up to 82% of the affected patients. Diabetic patients constitute around 30-35% of GP patients and it is estimated that up to 50% of type I (insulin dependent) diabetics and 30% of type 2 (noninsulin dependent) diabetics have symptoms consistent with GP.